The Paul F. Glenn Laboratories for Biology of Aging Research at the University of Michigan

a MiCDA Research Project Description

Investigators: Richard A. Miller, David Lombard, Zaneta Nikolovska-Coleska, Ao-Lin Hsu, Andrzej T. Galecki, Scott Pletcher, Raymond Yung, Charles Burant, Karl John Jepsen, Evan T. Keller, Henry Paulson

Funding: Glenn Foundation for Medical Research, 2014-2017 (Letter Agreement dated 8/21/14)

The Paul F. Glenn Center for Anti-Aging Medicine at the University of Michigan will focus on exploiting and expanding the growing evidence that drugs can slow aging and postpone diseases in animal models. The Center's activities will be directed towards three linked aims: (1) using simple model systems to rapidly identify and characterize new compounds that target evolutionarily conserved pathways that control aging; (2) facilitating the process by which candidate drugs are selected for longevity testing in mice; and (3) discovering the mechanisms by which drugs that extend lifespan achieve their effects. The central theme will be that learning how to slow aging in model systems will lead to breakthrough discoveries in our understanding of what times aging and how aging times the diseases of older adults, and that these breakthroughs, in turn, will lead to the development of practical anti-aging medications that postpone human diseases and extend healthy human lifespan.

Research Signature Theme:

Aging, Genetics, and Social Science