Kenneth M. Langa

Michigan Alzheimer's Disease Core Center

Research Project Description
Henry Paulson, Bruno J. Giordani, Benjamin Hampstead, Judith L. Heidebrink, Carol Catherine Persad, Edna Rose, Hiroko Dodge, Ivaylo D. Dinov, Yuanfang Guan, Jieping Ye, Andrew P. Lieberman, Sami J. Barmada, J. Scott Roberts, Nancy R. Barbas, Roger L. Albin, Kenneth M. Langa, David T. Burke, Laura Erica Rice-Oeschger, Raymond Yung, Jenna Wiens, Charles Burant, Neil Burton Alexander, Vikram Shakkottai, Sandra I. Camelo-Piragua, Sriram Venneti, Navid Seraji-Bozorgzad

Building on the existing, deep infrastructure in dementia and aging research at the University of Michigan (UM), the Michigan Alzheimer's Disease Core Center (Michigan ADCC) aims to foster and enhance innovative research in Alzheimer's disease (AD) and related dementias toward eventual preventive therapy. Recent advances have defined pathogenic mechanisms in AD, particularly the early and central role of ?-amyloid, but many potentially modifiable factors beyond ?-amyloid contribute to brain dysfunction and degeneration, yet remain poorly understood. Taking advantage of established strengths in brain imaging, metabolic disorders and mechanistic studies of neurodegenerative proteinopathies, the Michigan ADCC will emphasize, as its central theme, mechanistic research that seeks to identify, understand, and modulate the non-?-amyloid factors that contribute to brain dysfunction and neurodegeneration. A regional center, the Michigan ADCC will promote research across the UM campus, throughout the state of Michigan via collaborations with our partner universities Michigan State University and Wayne State University, and across the nation through collaborations with other ADC's and NIA-sponsored programs. The Michigan ADCC has four overarching goals: 1) Foster, catalyze and perform research of the highest potential impact in AD and related neurodegenerative disorders; 2) Promote regional efforts in understanding, diagnosing and treating AD and related dementias through collaborative scientific and outreach efforts; 3) Provide a wide range of training and research opportunities in the dementias
for health care professionals, scientists, and students through innovative educational and mentoring efforts; and 4) Collaborate with other ADCs, the NACC, and other multi-center research efforts to move the field closer to effective therapies for this group of devastating diseases. Success in achieving these goals will be ensured through the fully integrated activities of six Cores (Administrative; Clinical; Neuropathology; Data Management and Statistical; Outreach and Recruitment; and Research Education Component (RL5) Cores) and through close collaboration with related programs, including the newly established UM Protein Folding Diseases Initiative, Claude D. Pepper Older Americans Independence Center, Udall Center for Parkinson's Disease Research, Institute for Social Research, and the Michigan Center for Urban African American Aging Research, among many others. The impact of activities and research carried out by the Michigan ADCC will be enhanced by existing collaborations with other ADCs and NIA-supported programs, with the strong expectation that such collaborations will expand upon designation as an NIA-supported center.

National Institute on Aging
(1 P30 AG 053760 01)

Funding Period: 8/15/2016 to 6/30/2021