Cholinergic genetic effects on health and cognition in older adults: Longitudinal analysis
Investigators: Cindy Lustig
Funding: Michigan Center on the Demography of Aging, 2016-2017
The proposed research will address the how cholinergic genetics interact with age and other variables to affect cognition and health across the lifespan. Using genetic data from the database of genotypes and phenotypes (dbGaP) hosted by the National Center for Biotechnology Information (NCBI) in conjunction with data from participants in the Health and Retirement Study (HRS) conducted at UM, this pilot study will investigate the ways in which middle-aged and elderly carriers of a genetic polymorth that limits cholinergic capacity (lle89Val variant of SLC5A7) differ from non-carriers in cognitive and cardiac health.
Country of Focus: USA